The Toronto art scene is divided geographically into neighbourhoods. A little bit like the New York art scene, the older more prestigious galleries are grouped together uptown, where the edgey contemporary galleries can be found downtown.
Here are a few maps to organize a convient art walk in Toronto.
Yorkville is Toronto’s tres chic upscale neighbourhood. The neighbourhood hosts all the celebrities during the city’s prestigious Toronto International Film Festival. The galleries found there specialize in reputable, mid-career artists, as well as galleries featuring the big names in the art world.
In Downtown Toronto there is the predominant Queen West West district, a once decrepit stretch of by the hour hotels and abandoned buildings, now transformed into great boutiques, trendy bars, boutique hotels, and many many contemporary art spaces.

QUEEN WEST WEST, if you’re there you must see :

The MOCCA, Museum of Contemporary Canadian Art

MKG127 – A great space with really vibrant bright new artists

Paul Petro, with his two spaces, the main gallery and the tiny special projects gallery, always compelling new innovative artists.

Monte Clark Gallery and Stephen Bulger Gallery, showing great Canadian and international Photography.

Susan Hobbs gallery, slightly south of the Queen stretch.

401 Richmond is a great multi-tenant building, home to some wonderful galleries, plus the building itself has a great quality. Like the Prefix Photo gallery and WynickTuck.